Gut microbiome is associated with multiple sclerosis activity in children.
Mary K HortonKathryn McCauleyDouglas FadroshKei FujimuraJennifer GravesJayne NessYolanda WheelerMark P GormanLeslie A BensonBianca Weinstock-GuttmanAmy WaldmanMoses RodriguezJan-Mendelt TillemaLauren KruppAnita BelmanSoe MarMary RenselTanuja ChitinisTheron Charles CasperJohn RoseJanace HartXiaorong ShaoHelen TremlettSusan V LynchLisa F BarcellosEmmanuelle Waubantnull nullPublished in: Annals of clinical and translational neurology (2021)
Both individual and networks of gut microbes were associated with longitudinal multiple sclerosis activity. Known functions and metagenomic predictions of these microbes suggest the important role of butyrate and amino acid biosynthesis pathways. This provides strong support for future development of personalized microbiome interventions to modify multiple sclerosis disease activity.