Process data of allogeneic ex vivo-expanded ABCB5+ mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP.
Seda BallikayaSamar SadeghiElke Niebergall-RothLaura NimtzJens FrindertAlexandra NorrickNicole StemlerNicole BauerYvonne RoscheVanessa KratzenbergJulia PieperTina FicekMarkus H FrankChristoph GanssJasmina EsterlechnerMark Andreas KluthPublished in: Stem cell research & therapy (2020)
We have successfully established an expansion and manufacturing process that enables the generation of homogenous ABCB5+ MSC populations of proven biological activity manufactured as a standardized, donor-independent, highly pure, and highly functional off-the-shelf available ATMP, which is currently tested in multiple clinical trials.
Keyphrases
- clinical trial
- bone marrow
- endothelial cells
- stem cell transplantation
- electronic health record
- induced pluripotent stem cells
- pluripotent stem cells
- big data
- biofilm formation
- randomized controlled trial
- hematopoietic stem cell
- staphylococcus aureus
- machine learning
- escherichia coli
- pseudomonas aeruginosa
- deep learning
- candida albicans