Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.
Miguel Sáinz-JaspeadoRoss Osborne SmithOscar PlundeSven-Christian PawelzikYi JinSofia NordlingYindi DingPontus AspenströmMarie HedlundGiulia BastianelloFlora AscioneQingsen LiCansaran Saygili DemirDinesh FernandoGeoffrey DanielAnders Franco-CerecedaJeffrey KroonMarco FoianiTatiana V PetrovaManfred W KilimannMagnus BäckLena Claesson-WelshPublished in: Circulation (2021)
We identify RANGAP1 as a PALMD partner in ECs. Disrupting the PALMD/RANGAP1 complex alters the subcellular localization of RANGAP1 and XPO1, and leads to nuclear arrest of the XPO1 cargoes p53 and p21, accompanied by gene regulatory changes and loss of actin-dependent nuclear resilience. Combined, these consequences of reduced PALMD expression provide a mechanistic underpinning for PALMD's contribution to calcific aortic valve stenosis pathology.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- climate change
- aortic stenosis
- poor prognosis
- social support
- nitric oxide
- cell cycle
- heart failure
- cell proliferation
- stress induced
- long non coding rna
- ejection fraction
- human immunodeficiency virus
- hiv testing
- hiv infected
- heat stress