DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease.
Aleix Sala-VilaEider M Arenaza-UrquijoGonzalo Sánchez-BenavidesMarc Suárez-CalvetMarta Milà-AlomàOriol Grau-RiveraJosé M González-de-EchávarriMarta Crous-BouCarolina MinguillónKarine FauriaGrégory OpertoCarles FalcónGemma SalvadóRaffaele CacciagliaSilvia IngalaFrederik BarkhofHelmut SchröderNikolaos ScarmeasJuan-Domingo GispertJosé L Molinuevonull nullPublished in: The American journal of clinical nutrition (2021)
In cognitively unimpaired APOE-ε4 homozygotes, dietary DHA intake related to structural patterns that may result in greater resilience to AD pathology. This is consistent with the current hypothesis that those subjects at highest risk would obtain the largest benefits from DHA supplementation in the preclinical stage.This trial was registered at clinicaltrials.gov as NCT01835717.