Pan-RAF:MEK Molecular Glues Take Center Stage.
Matthew J HangauerJorge Silvio GutkindFleur M FergusonPublished in: Cancer discovery (2024)
In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).