Downregulation of Rad51 expression and activity potentiates the cytotoxic effect of osimertinib in human non-small cell lung cancer cells.
Jen-Chung KoJyh-Cheng ChenChing-Hsiu HuangPei-Jung ChenQiao-Zhen ChangBo-Cheng MuJun-Jie ChenTzu-Yuan TaiKasumi SuzukiYi-Xuan WangYun-Wei LinPublished in: Chemotherapy (2024)
Collectively, the downregulation of Rad51 expression and activity enhances the cytotoxic effect of osimertinib in human NSCLC cells.
Keyphrases
- small cell lung cancer
- endothelial cells
- poor prognosis
- advanced non small cell lung cancer
- dna damage
- signaling pathway
- induced apoptosis
- epidermal growth factor receptor
- cell proliferation
- induced pluripotent stem cells
- dna repair
- pluripotent stem cells
- single cell
- binding protein
- stem cells
- oxidative stress
- cell therapy
- cell cycle arrest
- long non coding rna
- bone marrow
- cell death
- brain metastases
- endoplasmic reticulum stress