Changes in neurologic status after traumatic brain injury in the Resuscitation Outcomes Consortium Hypertonic Saline trial.

Henry E WangChengcheng HuBruce J BarnhartJan O JansenKim MoellerDaniel W Spaite

Published in: Journal of the American College of Emergency Physicians open (2024)

Among TBI receiving initial prehospital care in the ROC-HS trial, changes in 6-month neurologic status followed distinct patterns. Among TBI with unfavorable neurologic status at hospital discharge, almost half improved to favorable neurologic status at 6 months. Among those with favorable neurologic status at discharge, very few worsened or died at 6 months. These findings have important implications for TBI clinical care, research, and trial design.

Keyphrases

traumatic brain injury
healthcare
study protocol
clinical trial
cardiac arrest
phase iii
severe traumatic brain injury
phase ii
quality improvement
randomized controlled trial
type diabetes
pain management
insulin resistance
mild traumatic brain injury
affordable care act
trauma patients