Peroxide-cleavable linkers for antibody-drug conjugates.
Nicola AshmanJonathan D BarghStephen J WalshRyan D GreenwoodArnaud TiberghienJason S CarrollDavid R SpringPublished in: Chemical communications (Cambridge, England) (2023)
Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro .