David R Spring (D R Spring)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 90

Top Topics

Pseudomonas Aeruginosa

Prostate Cancer

Top Venues

Chemical communications (Cambridge, England)

Chemical science

Proceedings of the National Academy of Sciences of the United States of America

Organic letters

This page only lists publications with an associated author ORCID identifier.

Publications

Thomas Wharton, Felicity Crawshay-Williams, Tim Schober, R Andres Floto, David R Spring
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules. Angewandte Chemie (International ed. in English) (2024)
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin Margarethe Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O'Brien, Amir Rafati Fard, Arman Godsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian James Patrick Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Novel immunotherapeutics against LGR5 to target multiple cancer types. EMBO molecular medicine (2024)
Poppy L Martin, Francisco Javier Pérez-Areales, Shalini V Rao, Stephen J Walsh, Jason S Carroll, David R Spring
Towards the Targeted Protein Degradation of PRMT1. ChemMedChem 19 (16) (2024)
Bruno M da S Santos, Fernanda G Finelli, David R Spring
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules. Organic letters (2024)
Raoul Walther, Mahri Park, Nicola Ashman, Martin Welch, Jason S Carroll, David R Spring
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs. Chemical communications (Cambridge, England) 60 (55) (2024)
Thomas Wharton, Felicity Crawshay-Williams, Tim Schober, R Andres Floto, David R Spring
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules. Angewandte Chemie (International ed. in English) 63 (18) (2024)
Thomas Wharton, Felicity Crawshay-Williams, Tim Schober, R Andres Floto, David R Spring
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules. Angewandte Chemie (International ed. in English) 63 (18) (2024)
Raoul Walther, Mahri Park, Nicola Ashman, Martin Welch, Jason S Carroll, David R Spring
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs. Chemical communications (Cambridge, England) 60 (55) (2024)
Raoul Walther, Mahri Park, Nicola Ashman, Martin Welch, Jason S Carroll, David R Spring
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs. Chemical communications (Cambridge, England) (2024)
Raoul Walther, Mahri Park, Nicola Ashman, Martin Welch, Jason S Carroll, David R Spring
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs. Chemical communications (Cambridge, England) 60 (55) (2024)
Poppy L Martin, Francisco Javier Pérez-Areales, Shalini V Rao, Stephen J Walsh, Jason S Carroll, David R Spring
Towards the Targeted Protein Degradation of PRMT1. ChemMedChem (2024)
Jack D Sydenham, Hikaru Seki, Sona Krajcovicova, Linwei Zeng, Tim Schober, Tomas Deingruber, David R Spring
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins. Chemical communications (Cambridge, England) 60 (6) (2024)
Jack D Sydenham, Hikaru Seki, Sona Krajcovicova, Linwei Zeng, Tim Schober, Tomas Deingruber, David R Spring
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins. Chemical communications (Cambridge, England) 60 (6) (2024)
Bruno M da S Santos, Fernanda G Finelli, David R Spring
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules. Organic letters 26 (19) (2024)
Bruno M da S Santos, Fernanda G Finelli, David R Spring
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules. Organic letters 26 (19) (2024)
Bruno M da S Santos, Fernanda G Finelli, David R Spring
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules. Organic letters 26 (19) (2024)
Thomas Wharton, Felicity Crawshay-Williams, Tim Schober, R Andres Floto, David R Spring
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules. Angewandte Chemie (International ed. in English) 63 (18) (2024)
Raoul Walther, Linda M Westermann, Sheiliza Carmali, Sophie E Jackson, Heike Brötz-Oesterhelt, David R Spring
Identification of macrocyclic peptides which activate bacterial cylindrical proteases. RSC medicinal chemistry 14 (6) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Mia Kapun, Francisco Javier Pérez-Areales, Nicola Ashman, Pamela J E Rowling, Tim Schober, Elaine Fowler, Laura S Itzhaki, David R Spring
Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution. RSC chemical biology 5 (1) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Nicola Ashman, Jonathan D Bargh, Stephen J Walsh, Ryan D Greenwood, Arnaud Tiberghien, Jason S Carroll, David R Spring
Peroxide-cleavable linkers for antibody-drug conjugates. Chemical communications (Cambridge, England) 59 (13) (2023)
Kim T Mortensen, Denedy S Y Wong, Thomas A King, Hannah F Sore, David R Spring
Synthesis of sp 3 -rich heterocyclic frameworks by a divergent synthesis strategy. Organic & biomolecular chemistry (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Teodors Pantelejevs, Pedro Zuazua-Villar, Oliwia Koczy, Andrew J Counsell, Stephen J Walsh, Naomi S Robertson, David R Spring, Jessica A Downs, Marko Hyvönen
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical science 14 (47) (2023)
Jessica Iegre, Sona Krajcovicova, Anders Gunnarsson, Lisa Wissler, Helena Käck, Anna Luchniak, Stefan Tångefjord, Frank Narjes, David R Spring
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction. Chemical science 14 (39) (2023)
Nicola Ashman, Jonathan D Bargh, Stephen J Walsh, Ryan D Greenwood, Arnaud Tiberghien, Jason S Carroll, David R Spring
Peroxide-cleavable linkers for antibody-drug conjugates. Chemical communications (Cambridge, England) 59 (13) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Jack D Sydenham, Hikaru Seki, Sona Krajcovicova, Linwei Zeng, Tim Schober, Tomas Deingruber, David R Spring
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins. Chemical communications (Cambridge, England) (2023)
Mia Kapun, Francisco Javier Pérez-Areales, Nicola Ashman, Pamela J E Rowling, Tim Schober, Elaine Fowler, Laura S Itzhaki, David R Spring
Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution. RSC chemical biology 5 (1) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Thomas A King, Stephen J Walsh, Mia Kapun, Thomas Wharton, Sona Krajcovicova, Melanie S Glossop, David R Spring
Disulfide re-bridging reagents for single-payload antibody-drug conjugates. Chemical communications (Cambridge, England) (2023)
Raoul Walther, Linda M Westermann, Sheiliza Carmali, Sophie E Jackson, Heike Brötz-Oesterhelt, David R Spring
Identification of macrocyclic peptides which activate bacterial cylindrical proteases. RSC medicinal chemistry 14 (6) (2023)
Nicola Ashman, Jonathan D Bargh, Stephen J Walsh, Ryan D Greenwood, Arnaud Tiberghien, Jason S Carroll, David R Spring
Peroxide-cleavable linkers for antibody-drug conjugates. Chemical communications (Cambridge, England) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Nicola Ashman, Jonathan D Bargh, Stephen J Walsh, Ryan D Greenwood, Arnaud Tiberghien, Jason S Carroll, David R Spring
Peroxide-cleavable linkers for antibody-drug conjugates. Chemical communications (Cambridge, England) 59 (13) (2023)
M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Abigail R Hanby, Stephen J Walsh, Andrew J Counsell, Nicola Ashman, Kim T Mortensen, Jason S Carroll, David R Spring
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy. Chemical communications (Cambridge, England) 58 (67) (2022)
Friederike M Dannheim, Stephen J Walsh, Carolina T Orozco, Anders Højgaard Hansen, Jonathan D Bargh, Sophie E Jackson, Nicholas J Bond, Jeremy S Parker, Jason S Carroll, David R Spring
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading. Chemical science 13 (30) (2022)
Stephen J Walsh, Soleilmane Omarjee, Friederike M Dannheim, Dominique-Laurent Couturier, Dorentina Bexheti, Lee Mendil, Gemma Cronshaw, Toby Fewster, Charlotte Gregg, Cara Brodie, Jodi L Miller, Richard Houghton, Jason S Carroll, David R Spring
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability. Chemical communications (Cambridge, England) 58 (12) (2022)
Nicola Ashman, Jonathan D Bargh, David R Spring
Non-internalising antibody-drug conjugates. Chemical Society reviews 51 (22) (2022)
Eleanor L Atkinson, Jessica Iegre, Claudio D'Amore, Paul D Brear, Mauro Salvi, Marko Hyvönen, David R Spring
Development of small cyclic peptides targeting the CK2α/β interface. Chemical communications (Cambridge, England) 58 (30) (2022)
Radu Costin Bizga Nicolescu, Zoe R Maylin, Francisco Javier Pérez-Areales, Jessica Iegre, Hardev S Pandha, Mohammad Asim, David R Spring
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI-001 in in vitro Models of Prostate Cancer Drug Resistance. ChemMedChem (2022)
Paul Brear, Claudia De Fusco, Eleanor L Atkinson, Jessica Iegre, Nicola J Francis-Newton, Ashok R Venkitaraman, Marko Hyvönen, David R Spring
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action. RSC medicinal chemistry 13 (11) (2022)
Bethany M Cooper, Jessica Iegre, Daniel H O' Donovan, Maria Ölwegård Halvarsson, David R Spring
Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs). Chemical Society reviews 50 (3) (2021)
Alexander V Strizhak, Oleg Babii, Sergii Afonin, Iuliia Bakanovich, Teodors Pantelejevs, Wenshu Xu, Elaine Fowler, Rohan S Eapen, Krishna Sharma, Maxim O Platonov, Vasyl V Hurmach, Laura Itzhaki, Marko Hyvönen, Anne S Ulrich, David R Spring, Igor V Komarov
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Organic & biomolecular chemistry 18 (28) (2021)
Bee-Ha Gan, Josephine S Gaynord, Sam M Rowe, Tomas Deingruber, David R Spring
The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions. Chemical Society reviews 50 (13) (2021)
Jessica Iegre, Eleanor L Atkinson, Paul D Brear, Bethany M Cooper, Marko Hyvönen, David R Spring
Chemical probes targeting the kinase CK2: a journey outside the catalytic box. Organic & biomolecular chemistry 19 (20) (2021)
Andrew J Counsell, Stephen J Walsh, Naomi S Robertson, Hannah F Sore, David R Spring
Efficient and selective antibody modification with functionalised divinyltriazines. Organic & biomolecular chemistry 18 (25) (2021)
Dawei Guo, Himansha Singh, Atsushi Shimoyama, Charlotte Guffick, Yakun Tang, Sam M Rowe, Timothy Noel, David R Spring, Koichi Fukase, Hendrik W van Veen
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent. Communications biology 4 (1) (2021)
Stephen J Walsh, Jessica Iegre, Hikaru Seki, Jonathan D Bargh, Hannah F Sore, Jeremy S Parker, Jason S Carroll, David R Spring
General dual functionalisation of biomacromolecules via a cysteine bridging strategy. Organic & biomolecular chemistry 18 (22) (2021)
Hikaru Seki, Stephen J Walsh, Jonathan D Bargh, Jeremy S Parker, Jason S Carroll, David R Spring
Rapid and robust cysteine bioconjugation with vinylheteroarenes. Chemical science 12 (26) (2021)
Eleanor L Atkinson, Jessica Iegre, Paul D Brear, Elizabeth A Zhabina, Marko Hyvönen, David R Spring
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study. Molecules (Basel, Switzerland) 26 (7) (2021)
Gabriele Fumagalli, Rodrigo J Carbajo, J Willem M Nissink, Jonathan Tart, Rongxuan Dou, Andrew P Thomas, David R Spring
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides. Journal of medicinal chemistry 64 (23) (2021)
Hannah L Stewart, Abigail R Hanby, Thomas A King, Andrew D Bond, Thomas A Moss, Hannah F Sore, David R Spring
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds. Chemical communications (Cambridge, England) 56 (50) (2020)
Peter R Curran, Chris J Radoux, Mihaela D Smilova, Richard A Sykes, Alicia P Higueruelo, Anthony R Bradley, Brian D Marsden, David R Spring, Tom L Blundell, Andrew R Leach, William R Pitt, Jason C Cole
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design. Journal of chemical information and modeling 60 (4) (2020)
Abigail R Hanby, Nikolaj S Troelsen, Thomas J Osberger, Sarah L Kidd, Kim T Mortensen, David R Spring
Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery. Chemical communications (Cambridge, England) 56 (15) (2020)
Alyssa C McVey, Sean Bartlett, Mahmud Kajbaf, Annalisa Pellacani, Viviana Gatta, Päivi Tammela, David R Spring, Martin Welch
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa. International journal of molecular sciences 21 (7) (2020)
Talia R Pettigrew, Rachel J Porter, Stephen J Walsh, Michael P Housden, Nelson Y S Lam, Jason S Carroll, Jeremy S Parker, David R Spring, Ian Paterson
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents. Chemical communications (Cambridge, England) 56 (10) (2020)
Thomas J Osberger, Sarah L Kidd, Thomas A King, David R Spring
C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection. Chemical communications (Cambridge, England) 56 (54) (2020)
Jiraborrirak Charoenpattarapreeda, Stephen J Walsh, Jason S Carroll, David R Spring
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angewandte Chemie (International ed. in English) 59 (51) (2020)
Jonathan D Bargh, Stephen J Walsh, Albert Isidro-Llobet, Soleilmane Omarjee, Jason S Carroll, David R Spring
Sulfatase-cleavable linkers for antibody-drug conjugates. Chemical science 11 (9) (2020)
David A Russell, Hannah R Bridges, Riccardo Serreli, Sarah L Kidd, Natalia Mateu, Thomas J Osberger, Hannah F Sore, Judy Hirst, David R Spring
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells. Journal of natural products 83 (6) (2020)
Julien J Freudenreich, Sean Bartlett, Naomi S Robertson, Sarah L Kidd, Suzie Forrest, Hannah F Sore, Warren R J D Galloway, Martin Welch, David R Spring
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin-Resistant Staphylococcus aureus (MRSA). ChemMedChem 15 (14) (2020)
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul D Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O' Donovan, Kilian V M Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical science 11 (39) (2020)
Attila Sveiczer, Andrew J P North, Natalia Mateu, Sarah L Kidd, Hannah F Sore, David R Spring
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection. Organic letters 21 (12) (2019)
Jiraborrirak Charoenpattarapreeda, Yaw Sing Tan, Jessica Iegre, Stephen J Walsh, Elaine Fowler, Rohan S Eapen, Yuteng Wu, Hannah F Sore, Chandra Shekhar Verma, Laura S Itzhaki, David R Spring
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides. Chemical communications (Cambridge, England) 55 (55) (2019)
Jessica Iegre, Paul D Brear, David J Baker, Yaw Sing Tan, Eleanor L Atkinson, Hannah F Sore, Daniel H O' Donovan, Chandra Shekhar Verma, Marko Hyvönen, David R Spring
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction. Chemical science 10 (19) (2019)
Kim T Mortensen, Thomas J Osberger, Thomas A King, Hannah F Sore, David R Spring
Strategies for the Diversity-Oriented Synthesis of Macrocycles. Chemical reviews 119 (17) (2019)
Thomas A King, Hannah L Stewart, Kim T Mortensen, Andrew J P North, Hannah F Sore, David R Spring
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery. European journal of organic chemistry 2019 (31-32) (2019)
Yuteng Wu, Amandeep Kaur, Elaine Fowler, Mareike M Wiedmann, Reginald Young, Warren R J D Galloway, Lasse Olsen, Hannah F Sore, Anasuya Chattopadhyay, Terence T-L Kwan, Wenshu Xu, Stephen J Walsh, Peterson de Andrade, Matej Janecek, Senthil Arumugam, Laura S Itzhaki, Yu Heng Lau, David R Spring
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides. ACS chemical biology 14 (3) (2019)
Naomi S Robertson, David R Spring
Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein⁻Protein Interactions. Molecules (Basel, Switzerland) 23 (4) (2018)
Stephen M Geddis, Teodora Coroama, Suzanne Forrest, James T Hodgkinson, Martin Welch, David R Spring
Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products. Beilstein journal of organic chemistry 14 (2018)
Jessica Iegre, Niaz S Ahmed, Josephine S Gaynord, Yuteng Wu, Kara M Herlihy, Yaw Sing Tan, Maria E Lopes-Pires, Rupam Jha, Yu Heng Lau, Hannah F Sore, Chandra Verma, Daniel H O' Donovan, Nicholas Pugh, David R Spring
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets. Chemical science 9 (20) (2018)
Stephen J Walsh, Soleilmane Omarjee, Warren R J D Galloway, Terence T-L Kwan, Hannah F Sore, Jeremy S Parker, Marko Hyvönen, Jason S Carroll, David R Spring
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical science 10 (3) (2018)
Jessica Iegre, Paul D Brear, Claudia De Fusco, Masao Yoshida, Sophie L Mitchell, Maxim Rossmann, Laura Carro, Hannah F Sore, Marko Hyvönen, David R Spring
Second-generation CK2α inhibitors targeting the αD pocket. Chemical science 9 (11) (2018)
Stephen J Walsh, Soleilmane Omarjee, Warren R J D Galloway, Terence T-L Kwan, Hannah F Sore, Jeremy S Parker, Marko Hyvönen, Jason S Carroll, David R Spring
Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical science 10 (2) (2018)
Natalia Mateu, Sarah L Kidd, Leen Kalash, Hannah F Sore, Andrew Madin, Andreas Bender, David R Spring
Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (51) (2018)
David G Twigg, Leonardo Baldassarre, Elizabeth C Frye, Warren R J D Galloway, David R Spring
Bioinspired Total Synthesis of Bussealin E. Organic letters 20 (6) (2018)
Daniel J Cole, Matej Janecek, Jamie E Stokes, Maxim Rossmann, John C Faver, Grahame J McKenzie, Ashok R Venkitaraman, Marko Hyvönen, David R Spring, David J Huggins, William L Jorgensen
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction. Chemical communications (Cambridge, England) 53 (67) (2018)
Alejandro Guarnieri-Ibáñez, Florian Medina, Céline Besnard, Sarah L Kidd, David R Spring, Jérôme Lacour
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes. Chemical science 8 (8) (2017)
Ysobel R Baker, J T Hodgkinson, B I Florea, E Alza, W R J D Galloway, L Grimm, S M Geddis, H S Overkleeft, M Welch, David R Spring
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes. Chemical science 8 (11) (2017)
David A Russell, Julien J Freudenreich, Joe J Ciardiello, Hannah F Sore, David R Spring
Stereocontrolled semi-syntheses of deguelin and tephrosin. Organic & biomolecular chemistry 15 (7) (2017)
Terence T-L Kwan, Omar Boutureira, Elizabeth C Frye, Stephen J Walsh, Moni K Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F Sore, Warren R J D Galloway, Jason W Chin, Martin Welch, Gonçalo J L Bernardes, David R Spring
Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst. Chemical science 8 (5) (2017)
Alyssa C McVey, Prasanthi Medarametla, Xavier Chee, Sean Bartlett, Antti Poso, David R Spring, Taufiq Rahman, Martin Welch
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa. Biochemistry 56 (41) (2017)
David A Russell, Winston J S Fong, David G Twigg, Hannah F Sore, David R Spring
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone. Journal of natural products 80 (10) (2017)
Stephen M Geddis, Laura Carro, James T Hodgkinson, David R Spring
Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489. European journal of organic chemistry 2016 (35) (2016)
Mareike M Wiedmann, Yaw Sing Tan, Yuteng Wu, Shintaro Aibara, Wenshu Xu, Hannah F Sore, Chandra S Verma, Laura S Itzhaki, Murray Stewart, James D Brenton, David R Spring
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer. Angewandte Chemie (International ed. in English) 56 (2) (2016)