Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention.
Ruyuf AlfurayhiLei HuangKirsten BrandtPublished in: Foods (Basel, Switzerland) (2023)
Polyacetylene phytochemicals are emerging as potentially responsible for the chemoprotective effects of consuming apiaceous vegetables. There is some evidence suggesting that polyacetylenes (PAs) impact carcinogenesis by influencing a wide variety of signalling pathways, which are important in regulating inflammation, apoptosis, cell cycle regulation, etc. Studies have shown a correlation between human dietary intake of PA-rich vegetables with a reduced risk of inflammation and cancer. PA supplementation can influence cell growth, gene expression and immunological responses, and has been shown to reduce the tumour number in rat and mouse models. Cancer chemoprevention by dietary PAs involves several mechanisms, including effects on inflammatory cytokines, the NF-κB pathway, antioxidant response elements, unfolded protein response (UPR) pathway, growth factor signalling, cell cycle progression and apoptosis. This review summarises the published research on falcarinol-type PA compounds and their mechanisms of action regarding cancer chemoprevention and also identifies some gaps in our current understanding of the health benefits of these PAs.
Keyphrases
- cell cycle
- oxidative stress
- papillary thyroid
- gene expression
- growth factor
- squamous cell
- cell proliferation
- anti inflammatory
- healthcare
- randomized controlled trial
- signaling pathway
- endoplasmic reticulum stress
- human health
- risk assessment
- cell cycle arrest
- heavy metals
- lymph node metastasis
- squamous cell carcinoma
- health information
- induced pluripotent stem cells
- health risk
- protein protein
- nuclear factor
- meta analyses