A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β.
Irene OliveraVicente MartínElixabet BolañosInmaculada RodriguezIñaki EtxeberríaAssunta CirellaJosune EgeaSaray GarasaItziar MiguelizIñaki EgurenMiguel F SanmamedJavier Glez-VazArantza AzpilikuetaMaite AlvarezMaría Carmen OchoaBeatrice MalacridaDavid J PropperCarlos E De AndreaPedro BerraondoFrances R BalkwillAlvaro TeijeiraIgnacio Melero BermejoPublished in: Cancer discovery (2022)
IL-8 attracts immunosuppressive protumor myeloid cells to the tumor microenvironment, and IL-8 levels correlate with poor response to checkpoint inhibitors. TNFα and IL-1β are identified as major inducers of IL-8 expression on malignant cells across cancer types and models in a manner that is druggable with clinically available neutralizing agents. This article is highlighted in the In This Issue feature, p. 2007.