Docosahexaenoic acid-acylated astaxanthin monoester ameliorates chronic high-fat diet-induced autophagy dysfunction via ULK1 pathway in the hypothalamus of mice.

Xiaoxu WangPeixu CongXincen WangZhigao WangBin LiuChanghu XueJie Xu

Published in: Journal of the science of food and agriculture (2023)

This study identified AST-DHA as an enhancer of autophagy that plays a beneficial role in restoring hypothalamic autophagy, and as a new potential therapeutic agent against HFD-induced obesity. © 2023 Society of Chemical Industry.

Keyphrases

high fat diet induced
insulin resistance
cell death
oxidative stress
endoplasmic reticulum stress
signaling pathway
high fat diet
diabetic rats
metabolic syndrome
fatty acid
adipose tissue
transcription factor
type diabetes
mouse model
drug induced
binding protein
weight loss
physical activity
wild type