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Cell-type-specific biomarkers of systemic sclerosis disease severity capture cell-intrinsic and cell-extrinsic circuits.

Jacob S BerkowitzTracy TabibHanxi XiaoGabrielle M SadejZsuzsanna H McMahanPatrizia FuschiottiRobert A LafyatisJishnu Das
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
Our global systems analyses uncover previous uncharacterized cell-intrinsic and cell-extrinsic signaling co-expression networks underlying SSc severity that involve keratinocytes, myeloid cells and fibroblasts. This article is protected by copyright. All rights reserved.
Keyphrases
  • systemic sclerosis
  • single cell
  • cell therapy
  • poor prognosis
  • bone marrow
  • induced apoptosis
  • cell proliferation
  • mesenchymal stem cells