Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity.
Harshi WeerakoonJasmin StraubeKatie E LineburgLeanne CooperSteven LaneCorey SmithSaleh AlabbasJakob BegunJohn J MilesMichelle M HillAilin LepletierPublished in: Clinical & translational immunology (2021)
Overall, our findings uncover the importance of CD49f expression on Treg in physiological immunity and in pathological autoimmunity.
Keyphrases
- regulatory t cells
- disease activity
- poor prognosis
- systemic lupus erythematosus
- rheumatoid arthritis
- ulcerative colitis
- rheumatoid arthritis patients
- endothelial cells
- ankylosing spondylitis
- dendritic cells
- binding protein
- juvenile idiopathic arthritis
- transcription factor
- nk cells
- peripheral blood
- long non coding rna
- single cell
- oxidative stress