Previous reports of a deficiency in Treg cell number or function in SLE are limited by their use of CD25, either alone or in combination with other markers, to identify human Treg cells. Helios in combination with FoxP3 is a superior method for detecting all non-cytokine-producing Treg cells, irrespective of CD25 or CD45RA expression. Using this method, we showed that FoxP3+Helios+ Treg cell numbers are not reduced in patients with clinically active SLE.
Keyphrases
- disease activity
- systemic lupus erythematosus
- induced apoptosis
- rheumatoid arthritis
- regulatory t cells
- cell cycle arrest
- ankylosing spondylitis
- single cell
- rheumatoid arthritis patients
- endothelial cells
- signaling pathway
- endoplasmic reticulum stress
- emergency department
- cell therapy
- oxidative stress
- stem cells
- poor prognosis
- bone marrow
- mesenchymal stem cells
- cell proliferation