Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer.
Mark S WilliamsNaseer J BasmaFabio M R AmaralGillian WilliamsJohn P WeightmanWolfgang BreitwieserLouisa NelsonStephen S TaylorDaniel H WisemanTim C P SomervaillePublished in: BMC cancer (2020)
Despite frequent high level expression of ABCB1 in relapsed primary AML we found no evidence of ABCB1 translocations and instead confirmed high-level activity of native ABCB1 promoters, consistent with endogenous regulation.