Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank.

Chen MoJingtao WangZhenyao YeHongjie KeSong LiuKathryn HatchSi GaoJessica MagidsonChixiang ChenBraxton D MitchellPeter KochunovL Elliot HongTianzhou MaShuo Chen

Published in: Addiction (Abingdon, England) (2022)

There appears to be a significant causal effect of smoking on the brain age gap, which suggests that smoking prevention can be an effective intervention for accelerated brain aging and the age-related decline in cognitive function.

Keyphrases

white matter
smoking cessation
resting state
multiple sclerosis
randomized controlled trial
cerebral ischemia
cross sectional