A Single Arm Phase 2 Trial of Trametinib in Patients With Locally Advanced or Metastatic Epithelioid Hemangioendothelioma.

Scott M Schuetze Karla V Ballman Rachel S Heise Kristen N Ganjoo Elizabeth J Davis Suzanne George Melissa A Burgess Edwin Choy Dale R Shepard Gabriel Tinoco Angela C Hirbe Ciara M Kelly Steven Attia Hari A Deshpande Gary K Schwartz Brittany L Siontis Richard F Riedel Margaret von Mehren Erin Kozlowski Helen X Chen Caroline Astbury Brian P Rubin

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Trametinib was associated with reduction in EHE-related pain and median PFS of more than 6 months providing palliative benefit in patients with advanced EHE, but the trial did not meet the ORR goal.

Keyphrases

locally advanced
squamous cell carcinoma
chronic pain
rectal cancer
neoadjuvant chemotherapy
small cell lung cancer
study protocol
pain management
phase iii
palliative care
clinical trial
neuropathic pain
phase ii
radiation therapy
phase ii study
randomized controlled trial
advanced cancer
open label