Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions.
Roberto Del Río-RodríguezMatthew T WestwoodMarina SicignanoMartin JuhlJosé A Fernández-SalasJosé AlemánAndrew D SmithPublished in: Chemical communications (Cambridge, England) (2022)
The photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates. The reaction proceeds VIA a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions.