Advances in Lung Cancer Treatment Using Nanomedicines.
Akshansh SharmaDevanshi ShambhwaniSadanand PandeyJay SinghHauzel LalhlenmawiaMurali KumarasamyDinesh Kumar ChellapanDinesh Kumar ChellappanGaurav GuptaParteek PrasherKamal DuaDeepak KumarPublished in: ACS omega (2022)
Carcinoma of the lungs is among the most menacing forms of malignancy and has a poor prognosis, with a low overall survival rate due to delayed detection and ineffectiveness of conventional therapy. Therefore, drug delivery strategies that may overcome undesired damage to healthy cells, boost therapeutic efficacy, and act as imaging tools are currently gaining much attention. Advances in material science have resulted in unique nanoscale-based theranostic agents, which provide renewed hope for patients suffering from lung cancer. Nanotechnology has vastly modified and upgraded the existing techniques, focusing primarily on increasing bioavailability and stability of anti-cancer drugs. Nanocarrier-based imaging systems as theranostic tools in the treatment of lung carcinoma have proven to possess considerable benefits, such as early detection and targeted therapeutic delivery for effectively treating lung cancer. Several variants of nano-drug delivery agents have been successfully studied for therapeutic applications, such as liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, hydrogels, and micelles. In this Review, we present a comprehensive outline on the various types of overexpressed receptors in lung cancer, as well as the various targeting approaches of nanoparticles.
Keyphrases
- drug delivery
- cancer therapy
- poor prognosis
- drug release
- gold nanoparticles
- carbon nanotubes
- high resolution
- end stage renal disease
- photodynamic therapy
- chronic kidney disease
- fluorescence imaging
- copy number
- newly diagnosed
- oxidative stress
- public health
- gene expression
- working memory
- dna methylation
- cell cycle arrest
- cell death
- fatty acid
- signaling pathway
- cell proliferation
- loop mediated isothermal amplification