Surgical closure, mainly with glue injection and anti-tumour necrosis factor α, in fistulizing perianal Crohn's disease: A multicentre randomized controlled trial.

Laurent AbramowitzCharlène BrochardFrançois PigotPauline RoumeguereHélène PillantBéatrice Vinson BonnetJean Luc FaucheronAgnès SenéjouxGuillaume BonnaudGuillaume MeuretteJean Marie FayetteCécile TrainGhislain StaumontLaurent SiproudhisDominique Bouchard

Published in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)

Seton removal alone seems to be no more effective than a secondary surgical step (in particular glue injection) in patients having fistulizing perianal CD controlled by an initial drainage combined with adalimumab. The results should be interpreted with caution.

Keyphrases

randomized controlled trial
end stage renal disease
ultrasound guided
study protocol
ejection fraction
newly diagnosed
chronic kidney disease
clinical trial
prognostic factors
peritoneal dialysis
systematic review
systemic lupus erythematosus
cross sectional
juvenile idiopathic arthritis