Oviductal Telocytes in Patients with Uterine Myoma.
Veronika AleksandrovychAnna WronaTomasz BerezaKazimierz PityńskiKrzysztof GilPublished in: Biomedicines (2021)
Tubal factor infertility occurs in 30-35% of infertile pairs and may be caused by impaired muscular contractility and ciliary beating as well as immunological imbalance and chronic inflammation. Newly discovered telocytes (TCs) have a wide palette of features, which play a role in oviduct physiology. We have observed tissue samples from human fallopian tubes in patients with and without uterine myoma by immunolabelling. According to the immunohistochemical co-expression of markers, it has been determined that TCs are engaged in a wide range of physiological processes, including local innervation, sensitivity to hypoxia, regulation of calcium, and sex steroid hormones balances. Due to the proximity of NOS- and ChAT-positive nerve fibers and the expression of ion channels markers, tubal TCs might be considered conductor cells. Additionally, their integration in contractions and cilia physiology in the context of fertility has been revealed. We have observed the difference in telocytes expression in the human oviduct between groups of patients and attempted to describe this population of cells specifically in the case of infertility development, a clinically relevant avenue for further studies.
Keyphrases
- poor prognosis
- endothelial cells
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- oxidative stress
- polycystic ovary syndrome
- binding protein
- induced pluripotent stem cells
- chronic kidney disease
- ejection fraction
- newly diagnosed
- pluripotent stem cells
- endoplasmic reticulum stress
- prognostic factors
- cell death
- type diabetes
- single cell
- skeletal muscle
- high intensity