PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.

Yen-Chun HoXin GengAnna O'DonnellJaime IbarrolaAmaya Fernandez-CelisRohan Varshney Kumar SubramaniZheila J Azartash-NaminJang KimRobert Silasi-Mansat Jill Wylie-Sears Zahra AlvandiLijuan ChenBoksik Cha Hong Chen Lijun Xia Bin ZhouFlorea LupuHarold M Burkhart Elena Aikawa Lorin E Olson Jasimuddin Ahamed Natalia Lopez-Andreés Joyce Bischoff Katherine E Yutzey Rajanarayanan Sathishkumar Srinivasan

Published in: Circulation research (2023)

PROX1 antagonizes PDGF-B signaling partially via FOXC2 to maintain the extracellular matrix composition and prevent myxomatous degeneration of cardiac valves.

Keyphrases

extracellular matrix
aortic valve
smooth muscle
aortic valve replacement
vascular smooth muscle cells
poor prognosis
heart failure
left ventricular
transcatheter aortic valve implantation
aortic stenosis
transcatheter aortic valve replacement