Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities.
Mariarosaria BoccellinoStefania D'AngeloPublished in: International journal of molecular sciences (2020)
The prevalence of obesity has steadily increased worldwide over the past three decades. The conventional approaches to prevent or treat this syndrome and its associated complications include a balanced diet, an increase energy expenditure, and lifestyle modification. Multiple pharmacological and non-pharmacological interventions have been developed with the aim of improving obesity complications. Recently, the use of functional foods and their bioactive components is considered a new approach in the prevention and management of this disease. Due to their biological properties, polyphenols may be considered as nutraceuticals and food supplement recommended for different syndromes. Polyphenols are a class of naturally-occurring phytochemicals, some of which have been shown to modulate physiological and molecular pathways involved in energy metabolism. Polyphenols could act in the stimulation of β-oxidation, adipocyte differentiation inhibition, counteract oxidative stress, etc. In this narrative review, we considered the association between polyphenols (resveratrol, quercetin, curcumin, and some polyphenolic extracts) and obesity, focusing on human trials. The health effects of polyphenols depend on the amount consumed and their bioavailability. Some results are contrasting, probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), and chemical forms of the dietary polyphenols used. But, in conclusion, the data so far obtained encourage the setting of new trials, necessary to validate benefic role of polyphenols in obese individuals.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- type diabetes
- weight gain
- high fat diet induced
- oxidative stress
- bariatric surgery
- adipose tissue
- risk factors
- physical activity
- healthcare
- public health
- skeletal muscle
- cardiovascular disease
- social media
- case report
- machine learning
- electronic health record
- climate change
- artificial intelligence
- fatty acid
- heat shock protein