Navigating the Nose-to-Brain Route: A Systematic Review on Lipid-Based Nanocarriers for Central Nervous System Disorders.
Edoardo AgostiMarco ZeppieriSara AntoniettiLuigi BattagliaTamara IusCaterina GaglianoMarco Maria FontanellaPier Paolo PancianiPublished in: Pharmaceutics (2024)
This systematic review reveals the transformative potential of intranasal lipid nanoparticles in treating brain diseases, overcoming the BBB. Positive outcomes highlight the effectiveness of SLNs and NLCs, which are promising new approaches for ailments from AD to stroke and gliomas. While celebrating progress, addressing challenges like nanoparticle toxicity is also crucial.
Keyphrases
- systematic review
- resting state
- white matter
- cerebral ischemia
- meta analyses
- blood brain barrier
- functional connectivity
- drug delivery
- randomized controlled trial
- fatty acid
- atrial fibrillation
- high grade
- oxidative stress
- cancer therapy
- multiple sclerosis
- adipose tissue
- risk assessment
- subarachnoid hemorrhage
- glycemic control