Disturbance of Adaptive Immunity System Was Accompanied by a Decrease in Plasma Short-Chain Fatty Acid for Patients Hospitalized During SARS-CoV-2 Infection After COVID-19 Vaccination.

Zhaojun LiangNan WangChunxue FanLili ShangYaping ZhangChong GaoJing Luo

Published in: Journal of inflammation research (2023)

Our study suggests the immune cell subsets in COVID-19 patients who had completed vaccination were still severely disturbed and concomitantly lower SCFAs, especially in severe patients with poor prognosis. Lower levels of plasma SCFAs may contribute to lymphopenia in COVID-19. The potential relationship between plasma SCFAs and immune cell reduction provides a new direction for the treatment of COVID-19.

Keyphrases

sars cov
coronavirus disease
poor prognosis
respiratory syndrome coronavirus
long non coding rna
fatty acid
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
peripheral blood
risk assessment
patient reported outcomes
climate change
combination therapy