XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions.

Yifei SunYihan ZhangJifeng ZhangY Eugene ChenJian-Ping JinKezhong ZhangHongmei MouXiubin LiangJie Xu

Published in: Cell & bioscience (2024)

The present work establishes a causal relationship between ER stress and SGLT1 upregulation and provides a mechanistic explanation why SGLT inhibitor drugs benefit diseases beyond diabetes.

Keyphrases

endothelial cells
type diabetes
cardiovascular disease
induced pluripotent stem cells
cell proliferation
poor prognosis
glycemic control
signaling pathway
pluripotent stem cells
metabolic syndrome
adipose tissue
skeletal muscle