Docosahexaenoic acid-acylated astaxanthin monoester ameliorates chronic high-fat diet-induced autophagy dysfunction via ULK1 pathway in the hypothalamus of mice.
Xiaoxu WangPeixu CongXincen WangZhigao WangBin LiuChanghu XueJie XuPublished in: Journal of the science of food and agriculture (2023)
This study identified AST-DHA as an enhancer of autophagy that plays a beneficial role in restoring hypothalamic autophagy, and as a new potential therapeutic agent against HFD-induced obesity. © 2023 Society of Chemical Industry.
Keyphrases
- high fat diet induced
- insulin resistance
- cell death
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- high fat diet
- diabetic rats
- fatty acid
- metabolic syndrome
- adipose tissue
- type diabetes
- skeletal muscle
- transcription factor
- drug induced
- high glucose
- mouse model
- body mass index
- weight gain
- physical activity
- stress induced