Activation of GPER1 by G1 prevents PTSD-like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection.
Lixia ChenYang ZhangZisheng WangZhengrong ZhangJingji WangGuoqi ZhuShaojie YangPublished in: CNS neuroscience & therapeutics (2024)
G1 improved PTSD-like behaviors in SPS mice, possibly by increasing hippocampal GPER1 expression and promoting BDNF/TrkB signaling to repair synaptic and mitochondrial functional impairments. This study would provide critical mechanism for the prevention and treatment of PTSD.
Keyphrases
- posttraumatic stress disorder
- social support
- high fat diet induced
- estrogen receptor
- poor prognosis
- oxidative stress
- cell death
- wild type
- reactive oxygen species
- insulin resistance
- adipose tissue
- binding protein
- metabolic syndrome
- skeletal muscle
- long non coding rna
- brain injury
- cerebral ischemia
- replacement therapy