Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43.
Y ImotoAtsushi KatoT TakabayashiM SakashitaJ E NortonL A SuhR G CarterA R WeibmanK E HulseW StevensK E HarrisA T PetersL C GrammerB K TanK WelchD B ConleyR C KernS FujiedaR P SchleimerPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Short-chain fatty acids were shown to induce airway epithelial cell expression of t-PA via GPR41 and GPR43. Topical delivery of potent compounds that activate these receptors may have value by reducing fibrin deposition and shrinking nasal polyp growth.
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