Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.
Chengpeng YuDean RaoTiantian WangJiaqi ShengEnjun LvLong ZhangXun LuJingjing YuHuifang LiangJia SongWenjie HuangPublished in: Journal of cellular and molecular medicine (2023)
Liver cancer is one of the most common solid tumours, and ranks as the third leading cause of cancer-associated mortality around the world. This study has linked RNF12 to the pathogenesis of liver cancer. Based on the analysis of patient samples and database data, high RNF12 expression was found in liver cancer, in correlation with worse clinicopathological features and a poor prognosis. Meantime, RNF12 could promote the progression of liver cancer in vitro and in vivo. Mechanistically, RNF12 could interact with EGFR and decrease the internalization of EGFR to activate EGF/EGFR signalling. In addition, PI3K-AKT signalling takes part in the regulation of liver cancer cell proliferation and migration of RNF12. And AKT inhibitor MK2206 could reverse RNF12-mediated cellular proliferation and migration in liver cancer. The possibility of the physical interaction between RNF12 and EGFR might lay a foundation to develop intervention strategies for liver cancer prevention and therapy.
Keyphrases
- poor prognosis
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- signaling pathway
- pi k akt
- dna damage response
- cell proliferation
- long non coding rna
- randomized controlled trial
- oxidative stress
- physical activity
- mental health
- risk factors
- case report
- type diabetes
- dna damage
- emergency department
- cardiovascular disease
- stem cells
- deep learning
- machine learning
- cell cycle arrest