Molecular characterization of colorectal cancer related peritoneal metastatic disease.
Kristiaan J LenosSander BachLeandro Ferreira MorenoSanne Ten HoornNina R SluiterSanne BootsmaFelipe A Vieira BragaLisanne E NijmanTom van den BoschDaniel M MiedemaErik van DijkBauke YlstraRuth KulickeFred P DavisNicolas StranskyGromoslaw A SmolenRobert R J Coebergh van den BraakJan Nicolaas Maria IJzermansJohn W M MartensSally HallamAndrew D BeggsGeert J P L KopsNico LansuVivian P BastiaenenCharlotte E L KlaverMaria C LeccaKhalid El MakriniClara C ElbersMark P G DingsCarel J M van NoeselOnno W KranenburgJan Paul MedemaJan KosterLianne KoensCornelis J A PuntPieter J TanisIgnace H de HinghMaarten F BijlsmaJurriaan B TuynmanLouis VermeulenPublished in: Nature communications (2022)
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.
Keyphrases
- particulate matter
- air pollution
- end stage renal disease
- ejection fraction
- heavy metals
- polycyclic aromatic hydrocarbons
- newly diagnosed
- squamous cell carcinoma
- chronic kidney disease
- small cell lung cancer
- healthcare
- prognostic factors
- peritoneal dialysis
- water soluble
- case report
- depressive symptoms
- mental health
- physical activity
- patient reported outcomes
- small molecule
- dna methylation
- social support
- patient reported
- binding protein
- drug induced