Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone.

Luz P BlancoHege L PedersenXinghao WangYaíma L LightfootNickie SetoCarmelo Carmona-RiveraZu-Xi YuVictoria HoffmannPeter S T YuenMariana J Kaplan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Idebenone ameliorates murine lupus disease activity and the severity of organ damage, supporting the hypothesis that agents that modulate mitochondrial biologic processes may have a therapeutic role in human SLE.

Keyphrases

disease activity
oxidative stress
rheumatoid arthritis
systemic lupus erythematosus
rheumatoid arthritis patients
ankylosing spondylitis
endothelial cells
juvenile idiopathic arthritis
induced pluripotent stem cells
pluripotent stem cells