Tumor-Suppressive and Oncogenic Roles of microRNA-149-5p in Human Cancers.
Yang ShenNan ZhaoNan ZhaoXinyao HuXiaoqin HeYangtao XuJiayu ChenWenliang ChenXin LiuZhuolin ZhouDedong CaoXiming XuPublished in: International journal of molecular sciences (2022)
Malignant tumors are always a critical threat to human health, with complex pathogenesis, numerous causative factors, and poor prognosis. The features of cancers, such as gene mutations, epigenetic alterations, and the activation and inhibition of signaling pathways in the organism, play important roles in tumorigenesis and prognosis. MicroRNA (miRNA) enables the control of various molecular mechanisms and plays a variety of roles in human cancers, such as radiation sensitivity and tumor immunity, through the regulation of target genes. MiR-149-5p participates in the process and is closely related to lipogenesis, the migration of vascular endothelial cells, and the expression of stem-cell-related proteins. In recent years, its role in cancer has dramatically increased. In this review, we summarize the regular physiological roles of miRNAs, specifically miR-149-5p, in the organism and discuss the tumor-suppressive or oncogenic roles of miR-149-5p in different human cancers with respect to signaling pathways involved in regulation. Possible clinical applications of miR-149-5p in future targeted therapies and prognosis improvement in oncology are suggested.
Keyphrases
- endothelial cells
- poor prognosis
- stem cells
- human health
- signaling pathway
- long non coding rna
- risk assessment
- induced pluripotent stem cells
- pluripotent stem cells
- gene expression
- high glucose
- climate change
- squamous cell carcinoma
- type diabetes
- pi k akt
- oxidative stress
- cell proliferation
- vascular endothelial growth factor
- bone marrow
- mesenchymal stem cells
- induced apoptosis
- binding protein
- endoplasmic reticulum stress
- radiation induced