Male sex adversely affects the phenotypic expression of diabetic heart disease.
Lavanya AthithanAmrit ChowdharyDaniel SwarbrickGaurav S GulsinAnvesha SinghNicholas JexManali JainJamal N KhanMatthew P M Graham-BrownJoanne V WormleightonKelly S ParkeMelanie J DaviesTheodoros KaramitsosKieran ClarkeStefan NeubauerEylem LeveltGaurav Singh GulsinPublished in: Therapeutic advances in endocrinology and metabolism (2020)
We aimed to determine the effect of sex on the phenotypic expression of diabetic heart disease in patients with T2D. While our findings support the notion that in T2D, male sex adversely affects the phenotypic expression of diabetic heart disease, this is in apparent conflict with the previous large-scale study showing diabetes attenuates the otherwise protective effect of female sex on progression of cardiomyopathy. Further longitudinal studies looking at gender differences in clinical outcomes in T2D patients are needed. These sex-related differences promote awareness of sex-specific risk factors in search of treatment and prevention of diabetes-associated HF.
Keyphrases
- type diabetes
- poor prognosis
- risk factors
- pulmonary hypertension
- end stage renal disease
- cardiovascular disease
- wound healing
- newly diagnosed
- ejection fraction
- chronic kidney disease
- binding protein
- glycemic control
- peritoneal dialysis
- magnetic resonance
- prognostic factors
- long non coding rna
- metabolic syndrome
- cross sectional
- insulin resistance
- weight loss
- adipose tissue
- drug induced
- case control