Improvement of Planning Abilities in Adults with Prader-Willi Syndrome: A Randomized Controlled Trial.
Séverine EstivalVirginie LaurierFabien MourreVirginie PostalPublished in: Developmental neurorehabilitation (2021)
Prader-Willi Syndrome (PWS) is a neurodevelopmental genetic disorder with executive deficits. Planning is one of the impaired executive functions implied in the regulation of behavior and everyday actions. We aimed to explore the feasibility and the effectiveness of a metacognitive strategy training designed to improve planning in adults with PWS using a double-blind between-group (training versus usual care) randomized controlled trial, with computerized tests and paper-pencil ecological outcome measures targeting planning, other executive functions, and achievement of personalized goal. Results showed better performances in several executive tasks and in achievement of personalized goals after both interventions, but better improvement for the experimental group (n = 27) compared to control (n = 26) only on the task assessing planning abilities. Interviews with occupational therapists demonstrated the feasibility of this training with this population. Despite a small number of sessions, the metacognitive strategy training showed encouraging results on planning abilities of patients.
Keyphrases
- randomized controlled trial
- working memory
- growth hormone
- virtual reality
- end stage renal disease
- healthcare
- chronic kidney disease
- ejection fraction
- traumatic brain injury
- gene expression
- climate change
- newly diagnosed
- study protocol
- case report
- physical activity
- risk assessment
- public health
- chronic pain
- peritoneal dialysis
- cancer therapy
- copy number
- health insurance
- global health
- clinical decision support
- congenital heart disease
- electronic health record
- human health