Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides .
Junki MiyamotoHidenori ShimizuKeiko HisaChiaki MatsuzakiShinsuke InukiYuna AndoAkari NishidaAyano IzumiMayu YamanoChihiro UshirodaJunichiro IrieTakane KatayamaHiroaki OhnoHiroshi ItohKenji YamamotoIkuo KimuraPublished in: Gut microbes (2023)
Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides ; however, the exact mechanism of action of these foods remains unclear. Here, we observed that prebiotics associated with L. mesenteroides -produced exopolysaccharides (EPS) demonstrate substantial host metabolic benefits. L. mesenteroides -produced EPS is an indigestible α-glucan, and intake of the purified form of EPS improved glucose metabolism and energy homeostasis through EPS-derived gut microbial short-chain fatty acids, and changed gut microbial composition. Our findings reveal an important mechanism that accounts for the effects of diet, prebiotics, and probiotics on energy homeostasis and suggests an approach for preventing lifestyle-related diseases by targeting bacterial EPS.
Keyphrases
- lactic acid
- microbial community
- fatty acid
- physical activity
- weight loss
- healthcare
- metabolic syndrome
- mental health
- cardiovascular disease
- type diabetes
- genome wide
- dna methylation
- gene expression
- risk assessment
- health information
- single cell
- density functional theory
- climate change
- human health
- drug induced
- molecular dynamics