Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor-positive Breast Cancers.

Milana A BergaminoGabriele MoraniJoel S ParkerEugene F SchusterMariana F LealElena López-KnowlesHolly ToveyJudith M BlissJohn F R RobertsonIan E SmithMitch DowsettMaggie Chon U Cheang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Tumor transcriptional profiles undergo bigger changes in response to longer NET. Changes in HER2-enriched and Luminal B subtypes are similar between the two cohorts, thus AI-sensitive intrinsic subtype tumors associated with good survival might be identified after 2 weeks of AI. The changes of immune-checkpoint component expression in early AI resistance and its impact on survival outcome warrants careful investigation in clinical trials.

Keyphrases

estrogen receptor
artificial intelligence
clinical trial
poor prognosis
rectal cancer
gene expression
lymph node
machine learning
deep learning
locally advanced
binding protein
randomized controlled trial
radiation therapy
heat shock
young adults
phase ii
heat stress