Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease.
Xin ZhouXiaotao ShenJethro S JohnsonDaniel J SpakowiczMelissa AgnelloWenyu ZhouMonica AvinaAlexander HonkalaFaye ChleilatShirley Jingyi ChenKexin ChaShana LeopoldChenchen ZhuLei ChenLin LyuDaniel HornburgSi WuXinyue ZhangChao JiangLiuyiqi JiangLihua JiangRuiqi JianAndrew W BrooksMeng WangKévin ContrepoisPeng GaoSophia Miryam Schüssler-Fiorenza RoseThi Dong Binh TranHoan NguyenAlessandra CelliBo-Young HongEddy J BautistaYair DorsettPaula KavathasYanjiao ZhouErica SodergrenGeorge M WeinstockMichael P SnyderPublished in: bioRxiv : the preprint server for biology (2024)
The stability of the human microbiome varies among individuals and body sites.Highly individualized microbial genera are more stable over time.At each of the four body sites, systematic interactions between the environment, the host and bacteria can be detected.Individuals with insulin resistance have lower microbiome stability, a more diversified skin microbiome, and significantly altered host-microbiome interactions.