Clinical and Functional Characteristics of a Novel KLF11 Cys354Phe Variant Involved in Maturity-Onset Diabetes of the Young.
Yujing SunJingru QuJing WangRuxing ZhaoChuan WangLi ChenXinguo HouPublished in: Journal of diabetes research (2021)
Herein, for the first time, we report a novel KLF11 (c.1061G > T) monogenic mutation associated with MODY7. This variant has impaired insulin promoter regulation activity and impairs insulin expression and secretion in pancreatic beta cells. Therefore, administering oral antidiabetic drugs along with dietary intervention may benefit the proband.
Keyphrases
- type diabetes
- glycemic control
- transcription factor
- induced apoptosis
- poor prognosis
- randomized controlled trial
- cell cycle arrest
- dna methylation
- gene expression
- endoplasmic reticulum stress
- insulin resistance
- oxidative stress
- binding protein
- cell death
- signaling pathway
- metabolic syndrome
- adipose tissue
- middle aged
- cell proliferation