Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing.

Melinda A PruisFloris H GroenendijkK Sangeeta BadloeAndrea van PuffelenDebbie G J RobbrechtWinand N M DinjensStefan SleijferAnne-Marie C Dingemans Jan H von der ThusenPaul RoepmanMartijn Paul Lolkema

Published in: British journal of cancer (2022)

WGS on fresh FF biopsies is a feasible tool for the selection of personalised experimental therapy in patients with advanced cancer without SOC options. WGS is now possible in an acceptable TAT and thus could fulfil the role of a universal genomic pre-screening test.

Keyphrases

advanced cancer
palliative care
papillary thyroid
squamous cell
copy number
gene expression
combination therapy
cell therapy