A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation.

Filipe Martins Olga Rosspopoff Joana Carlevaro-Fita Romain Forey Sandra Offner Evarist Planet Cyril Pulver HuiSong Pak Florian Huber Justine Michaux Michal Bassani-Sternberg Priscilla Turelli Didier Trono

Published in: Cancer research (2024)

Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate the development of improved biomarkers and treatments.

Keyphrases

stress induced
oxidative stress
papillary thyroid
oxide nanoparticles
poor prognosis
squamous cell
signaling pathway
mouse model