A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation.

Filipe MartinsOlga RosspopoffJoana Carlevaro-FitaRomain ForeySandra OffnerEvarist PlanetCyril PulverHuiSong PakFlorian HuberJustine MichauxMichal Bassani-SternbergPriscilla TurelliDidier Trono
Published in: Cancer research (2024)
Upregulation of a cluster of primate-specific KRAB zinc finger proteins in cancer cells prevents replicative stress and inflammation by regulating heterochromatin maintenance, which could facilitate the development of improved biomarkers and treatments.