Four-week inhibition of the renin-angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks.

Sean G ByarsPriscilla R PrestesVaraporn SuphapimolFumihiko TakeuchiNathan De VriesMichelle C MaierMariana MeloDavid BaldingNilesh SamaniAndrew M AllenNorihiro KatoJennifer L Wilkinson-BerkaFadi CharcharStephen B Harrap

Published in: Cardiovascular research (2024)

Early RAS inhibition in SHR resets genetic pathways and networks resulting in a legacy of reduced Ren expression and BP persisting for a minimum of 6 weeks.

Keyphrases

poor prognosis
blood pressure
genome wide
copy number
randomized controlled trial
long non coding rna
heart rate
clinical trial
gene expression
dna methylation
study protocol
wild type
genome wide identification