Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole-induced seizures in rats.
Hatice AygunAli Tuğrul AkinNildem KızılaslanOrhan SumbulDerya KarabulutPublished in: European journal of neurology (2022)
Our results suggest that probiotic supplementation may alleviate seizure severity and exert neuroprotective effects by reducing neuroinflammation and oxidative stress and altering the expression of neurotrophins in epileptogenic brains.
Keyphrases
- oxidative stress
- diabetic rats
- poor prognosis
- bacillus subtilis
- high glucose
- traumatic brain injury
- temporal lobe epilepsy
- lipopolysaccharide induced
- dna damage
- lactic acid
- ischemia reperfusion injury
- cognitive impairment
- lps induced
- drug induced
- binding protein
- long non coding rna
- induced apoptosis
- cerebral ischemia
- brain injury
- signaling pathway