Progress in Bioengineering Strategies for Heart Regenerative Medicine.
Timm HänekeMakoto SaharaPublished in: International journal of molecular sciences (2022)
The human heart has the least regenerative capabilities among tissues and organs, and heart disease continues to be a leading cause of mortality in the industrialized world with insufficient therapeutic options and poor prognosis. Therefore, developing new therapeutic strategies for heart regeneration is a major goal in modern cardiac biology and medicine. Recent advances in stem cell biology and biotechnologies such as human pluripotent stem cells (hPSCs) and cardiac tissue engineering hold great promise for opening novel paths to heart regeneration and repair for heart disease, although these areas are still in their infancy. In this review, we summarize and discuss the recent progress in cardiac tissue engineering strategies, highlighting stem cell engineering and cardiomyocyte maturation, development of novel functional biomaterials and biofabrication tools, and their therapeutic applications involving drug discovery, disease modeling, and regenerative medicine for heart disease.
Keyphrases
- tissue engineering
- stem cells
- pluripotent stem cells
- poor prognosis
- heart failure
- endothelial cells
- drug discovery
- left ventricular
- pulmonary hypertension
- atrial fibrillation
- long non coding rna
- gene expression
- cell therapy
- risk factors
- induced pluripotent stem cells
- type diabetes
- machine learning
- body mass index
- angiotensin ii
- cardiovascular disease
- deep learning