Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.

Katia K Mattis Nicole A J Krentz Christoph MetzendorfFernando AbaituaAliya F Spigelman Hanice Sun Jennifer M Ikle Swaraj Thaman Antje K GrotzAustin BautistaEugenia MazzaferroMarta Perez-Alcantara Jocelyn E Manning Fox Jason M Torres Agata Wesolowska-AndersenGrace Z YuAnubha Mahajan Anders O Larsson Patrick Edward MacDonald Benjamin Davies Marcel den Hoed Anna L Gloyn

Published in: Diabetologia (2023)

Together, our results indicate that RREB1 regulates beta cell function by transcriptionally regulating the expression of genes involved in beta cell development and function.

Keyphrases

gene expression
single cell
cell therapy
type diabetes
induced apoptosis
poor prognosis
dna methylation
binding protein
metabolic syndrome
long non coding rna
signaling pathway
weight loss
glycemic control