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Sacituzumab Govitecan Demonstrates Efficacy across Tumor Trop-2 Expression Levels in Patients with Advanced Urothelial Cancer.

Yohann LoriotArjun V BalarDaniel P PetrylakArash Rezazadeh KalebastyPetros D GrivasAude FlechonRohit K JainUmang SwamiManojkumar BupathiPhilippe BarthélémyPhilippe BeuzebocPhillip L PalmbosChristos E KyriakopoulosDamien PouesselCora N SternbergJulia TonelliMitch SiereckiMarianna ZavodovskayaEmon ElboudwarejLauri DiehlJuliane M JürgensmeierScott T Tagawa
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Trop-2 protein is highly expressed in UC, as confirmed by examining tumors from patients enrolled in the TROPHY-U-01 trial. The results indicate that SG demonstrates efficacy in mUC across Trop-2 expression levels.
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