Sacituzumab Govitecan Demonstrates Efficacy across Tumor Trop-2 Expression Levels in Patients with Advanced Urothelial Cancer.

Yohann Loriot Arjun V Balar Daniel P Petrylak Arash Rezazadeh Kalebasty Petros D Grivas Aude Flechon Rohit K Jain Umang Swami Manojkumar Bupathi Philippe Barthélémy Philippe Beuzeboc Phillip L Palmbos Christos E Kyriakopoulos Damien Pouessel Cora N Sternberg Julia Tonelli Mitch Sierecki Marianna Zavodovskaya Emon Elboudwarej Lauri Diehl Juliane M Jürgensmeier Scott T Tagawa

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Trop-2 protein is highly expressed in UC, as confirmed by examining tumors from patients enrolled in the TROPHY-U-01 trial. The results indicate that SG demonstrates efficacy in mUC across Trop-2 expression levels.

Keyphrases

poor prognosis
end stage renal disease
binding protein
newly diagnosed
ejection fraction
chronic kidney disease
clinical trial
papillary thyroid
study protocol
squamous cell carcinoma
long non coding rna
randomized controlled trial