Restoring microRNA-34a overcomes acquired drug resistance and disease progression in human breast cancer cell lines via suppressing the ABCC1 gene.
Shaymaa M M YahyaHeba K NabihGhada H ElsayedShimaa Ibrahim Abdelmenym MohamedAsmaa M ElfikySohair M SalemPublished in: Breast cancer research and treatment (2023)
The ectopic expression of miRNA-34a ameliorates the acquired drug resistance and the migration properties that may eventually lead to improved clinical strategies and outcomes for breast cancer patients. Additionally, miRNA-34a could be monitored as a diagnostic/prognostic biomarker for resistant conditions.