Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis.

Amanda FitzpatrickMarjan Iravani Adam MillsLucy ChildsThanussuyah AlaguthuraiAngela CliffordIsaac Garcia-MurillasSteven Van LaereLuc DirixMark HarriesAlicia F C OkinesNicholas C TurnerSyed HaiderAndrew N J Tutt Clare M Isacke

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Measuring ctDNA fraction by ulpWGS is a quantitative marker demonstrating potential for timely and accurate BCLM diagnosis and therapy response monitoring, with the ultimate aim to improve management of this poor-prognosis patient group.

Keyphrases

poor prognosis
long non coding rna
high resolution
circulating tumor
cerebrospinal fluid
case report
small cell lung cancer
stem cells
risk assessment
human health
cell free
circulating tumor cells
replacement therapy