AhR mediates an anti-inflammatory feedback mechanism in human Langerhans cells involving FcεRI and IDO.

S KochT J StroischJ VoracN HerrmannNicole LeibS SchnautzH KirinsI FörsterH WeighardtT Bieber

Published in: Allergy (2017)

Our study shows that AhR activation by FICZ reduces FcεRI and upregulates IDO expression in LC. This AhR-mediated anti-inflammatory feedback mechanism may dampen the allergen-induced inflammation in AD.

Keyphrases

anti inflammatory
induced apoptosis
endothelial cells
oxidative stress
poor prognosis
diabetic rats
cell cycle arrest
pluripotent stem cells
binding protein
endoplasmic reticulum stress
signaling pathway
cell proliferation